I don't live in Florida, but if it were up to me, I would. We both love the St. Augustine and Ormond Beach area of the state. However, DW can't be away from her kids and grandkids for more than a 6-8 extended RV trip.
I think those drive times are a little long. When we stayed at Big Lagoon SP in Pensacola last February and drove down to see my BIL's new condo in Cape Coral, errr Ft. Myers area, it took us less than 9 hours to get there. And, Jacksonville is under 400 miles from Pensacola, maybe a 6-hour drive at most, and probably less.