I'm gonna enjoy watching this thread!
Work from, can be tricky! For instance. My vision is towing a cargo trailer behind that would serve as a shop. Others would be thinking about how to dual purpose an office space. I will only cover those two views knowing that the answer is as diverse as life itself!
I lean towards older, low price options, because modifying the interior will not change the value much! Or may greatly improve saleablity should you become disheartened with the lifestyle.
I liken the right floor plan, with intent to live in the environment, to choosing what motel room to live in! The appeal will dye in short order unless you make it yours. Then as fulltimers you will need to store what you take out, so you can return your home to original, so original value can be maintained.
The most content fulltimers have followed this path! After all it will be your home, and you want that feel not the feel you are in someone else's motel. Every one of my RVS was extensively modified to suit myself and my better half, except for the one I had to worry about value. I was least content with that one.
As would be said to someone looking at building a tiny house. You should plan for reduced space while not changing your lifestyle. It is still your home!!!
Oh yah!!! My best fit is 5th towing a cargo (shop)... cargos also make great office space.