I try to avoid the interstates and run US and State highways. That said, I also understand that there are a lot of slower drivers on the rural highways. I understand that there are a lot of people who think the speed limit doesn't apply to them. I understand there are a lot of drivers that are driving "distracted" due to cellphones, pets, kids, radios, passengers, etc. I figure I need to drive defensively. And expect stupidity from all drivers. If someone gets near me, I keep a sharper eye on them.
As for truckers... like any one driving any vehicle, there are good drivers and bad drivers. Generally I feel safer with a trucker than I do with another RVer (unless it's a logging truck or a Swift driver.... which seems to be the same thing or they just drive the same). I've had far more near misses with RVers than I've had with truckers. And there's more truckers on the highways I travel than there are RVs.
RVers tend to think they are either entitled or they are unconscious as to what size their RV is. I'm leaning towards "entitled". I generally assume that if they are traveling with a little dog/cat (or two) wandering around on the dash, then they are an accident waiting to happen. I try to stay as far away from them as I can.
Another good example are the idiots that are currently parked next to me. When they backed in, they took out the 4X4 post with the site number on it... along with my now flattened solar stick light ON a thin pole that stuck up about 40" above the ground. I've noticed they haven't bothered to apologize for running it down and they've been here 3 days so far. Currently their big truck used to tow their fiver is parked so it is into the single lane drive by about 3 ft. How considerate of them. My old jeep is parked across the drive in the overflow parking and it's a good thing because they would have taken out my jeep otherwise. As it is, I checked to see if they had hit it when they backed their fiver into the site. And I will check every day while they are here. It's THIS mindset that indicates a bad driver.
I live in an RV park and have since 2005. I've watched a lot of bad drivers on interior park roads. I cringe to think they are out on the highways.