I made the trip from AZ to Homer AK in 2015 the problem I had was the large gravel on the Alcan and in Alaska itself, both windshields got shattered. I swear they use 1" minus for snow removal. The alcan was pretty rough going up but not bad coming back. I would look into windshield treatments to protect the glass and windshield patch kits.
Got snowed in at Liard hot spring for 10 days that was nice had the whole place to ourselves pretty much, they sold firewood there, that was April or May the following year on the way back, stayed at a friends place during the winter?
Saw a few bison, wildlife on the way up but 100's on the way back (by Liard) along with mountain goats and a few black bear.
They were requiring the covid jab as of 2020 to cross the Canada border not sure if they are any longer? I won't go back for that reason alone, I will take the ferry from Washington next trip, heard it was beautiful. Your phone will not work up through Canada unless you purchase one there which we did. Some of the route it was 300km between towns so be prepared with all you will need. We stayed in Canada for a few months looking around on the way back. They will search your RV going in and coming back, you will have to give them any firewood you are carrying and they will ask you how long you are staying in Canada I just told them long enough to get through. You can't carry pepper spray for defense against people, you have to surrender it, not sure if they will let you carry bear spray in, stupid laws.
You can bring a firearm but you have to follow their regs exactly and prefill out paperwork and sign it in front of them. Mine I just left in storage in Montana and borrowed one when I was up there I forgot a box of ammo I had but they never found it thank God if you don't declare anything they consider illegal they will arrest you. Alaska you can't buy a firearm unless you have been there for a year.