I installed the "Ford Ultratune", from Ultra RV, in my 2020 Newmar Canyon Star, but it's on a 2019, 26,000GVWR, F-53, V-10 chassis!
Overall performance seemed to increase, especially initial acceleration, and definitely improved the shift points, reducing the need for more frequent shifts.
Fuel mileage seemingly did not increase, and stays about 6.6-6.9 mpg towing a 2017 GMC Terrain. Without the Terrain, I got 8.2-8.5 mpg!
In my opinion, the best results were in the change of shift patterns, & not upshifting/downshifting with as much frequency!
Nothing to do with performance, but I removed the "dog house", and added "Dynamat" Insulation pad, and noise reduction pad, and as a result, significantly reduced the engine noise in the front of the coach! A GREAT improvement!